Information for Clinicians

Charing Cross Hospital (CXH) Trophoblast Disease Clinic Guide

Chemotheraphy Regemins For Trophoblast Disease

Methotrexate/Folinic acid treatment schedule

Day 1 Methorexate 50mg im at noon
Day 2 Folinic acid 15mg po at 6pm
Day 3 Methorexate 50mg im at noon
Day 4 Folinic acid 15mg po at 6pm
Day 5 Methorexate 50mg im at noon
Day 6 Folinic acid 15mg po at 6pm
Day 7 Methorexate 50mg im at noon
Day 8 Folinic acid 15mg po at 6pm

EMA-CO chemotherapy

Week 1
     Day 1 Actinomycin-D 0.5mg iv
          Etoposide 100mg/m2 iv
          Methotrexate 300mg/m2 iv
     Day 2 Actinomycin-D 0.5mg iv
          Etoposide 100mg/m2 iv
          Folinic acid 15mg po 12 hourly x 4 doses
          Starting 24hrs after commencing methotrexate

Week 2
     Day 8 Vincristine 0.8mg/m2 (max 2mg)
          Cyclophosphamide 600mg/m2

EP/EMA chemotherapy

Week 1
     Day 1 Actinomycin-D 0.5mg iv
          Etoposide 100mg/m2 iv
          Methotrexate 300mg/m2 iv
     Day 2 Folinic acid 15mg po 12 hourly x 4 doses
          Starting 24hrs after commencing methotrexate

Week 2
     Day 8 Etoposide 150mg/m2 iv
          Cisplatin 75 mg/m2 iv

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