The abnormal proliferation of gestational trophoblast tissue forms a spectrum of disease from the generally benign partial hydatidiform mole through to malignant forms of the illness, choriocarcinoma and placental site trophoblast tumours. The biology, diagnosis and treatment of these diseases makes trophoblast disease an extremely important and interesting area of gynaecological and oncology care. Although these illnesses are all rare, patients generally have successful outcomes with total cure rates in excess of 95%. In this clinic guide we will give some background information, but mainly concentrate on the assessment and treatment of these rare patients.
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