Methotrexate/Folinic acid treatment schedule
Day 1 Methorexate 50mg im at noon
Day 2 Folinic acid 15mg po at 6pm
Day 3 Methorexate 50mg im at noon
Day 4 Folinic acid 15mg po at 6pm
Day 5 Methorexate 50mg im at noon
Day 6 Folinic acid 15mg po at 6pm
Day 7 Methorexate 50mg im at noon
Day 8 Folinic acid 15mg po at 6pm
Actinomycin D Pulse
2mg IV every 2 weeks
EMA-CO chemotherapy
Week 1
Day 1 Actinomycin-D 0.5mg iv
Etoposide 100mg/m2 iv
Methotrexate 300mg/m2 iv
Day 2 Actinomycin-D 0.5mg iv
Etoposide 100mg/m2 iv
Folinic acid 15mg po 12 hourly x 4 doses
Starting 24hrs after commencing methotrexate
Week 2
Day 8 Vincristine 0.8mg/m2 (max 2mg)
Cyclophosphamide 600mg/m2
EP/EMA chemotherapy
Week 1
Day 1 Actinomycin-D 0.5mg iv
Etoposide 100mg/m2 iv
Methotrexate 300mg/m2 iv
Day 2 Folinic acid 15mg po 12 hourly x 4 doses
Starting 24hrs after commencing methotrexate
Week 2
Day 8 Etoposide 150mg/m2 iv
Cisplatin 75 mg/m2 iv